Changes in liver tissue structure under the influence of moderate ischemia in conditions of enhanced antioxidant defense system

Abstract

This experimental study investigated the morphological changes in white rat liver tissue subjected to moderate ischemia (5 minutes) after prior administration of the antioxidant Mexidol. Histological examination 15 minutes post-ischemia showed no significant alterations in lobular architecture, hepatocyte integrity, or portal tract structures. Minor changes included slight edema, widened Disse spaces, and dilated, blood-congested sinusoids. Mild dystrophic changes were limited to some hepatocytes near the portal tracts. The results suggest a cytoprotective role of Mexidol and enhanced antioxidant defense in mitigating ischemia-induced liver injury, keeping changes within the limits of compensatory structural adaptation.