The influence of vitamin D concentration on the course of atopic dermatitis in children

Abstract

The study investigated the relationship between serum vitamin D (25(OH)D) concentration and the severity of atopic dermatitis (AtD), as well as food allergen sensitization in 44 children. Results showed that 25(OH)D levels were significantly lower in children with AtD compared to healthy controls (56% of AtD patients had deficiency/insufficiency). A strong inverse correlation was found: the more severe the AtD (higher SCORAD index), the lower the 25(OH)D concentration ($p=0.015$). Similar findings were observed in children with food sensitization. The study confirms that oxidative stress intensifies in DM and that vitamin D application contributes to the increase of antioxidative capacity, suggesting its role in pathogenetic correction.