Small doses of carbon monoxide from the CORM-2 donor drug reduce ischemia-reperfusion damage to the heart
Дата
2024
Автори
Назва журналу
Номер ISSN
Назва тому
Видавець
ПВНЗ «Харківський міжнародний медичний університет»
Анотація
The study investigates the cardioprotective effects of small doses of carbon monoxide released from the donor drug CORM-2 during ischemia-reperfusion injury in isolated mouse hearts. Administration of CORM-2 stabilized coronary flow, reduced Ca²⁺ deposition, and decreased creatinine and aspartate aminotransferase release, indicating improved mitochondrial function and reduced cytoplasmic membrane damage. Electrophysiological analysis revealed modulation of ventricular depolarization, particularly changes in the amplitude of the R wave. These findings suggest that CORM-2 exerts protective effects against ischemia-reperfusion injury, likely through interactions with calcium channels and energy metabolism, supporting its potential as a therapeutic agent in myocardial ischemia.
Опис
Ключові слова
CORM-2, carbon monoxide donor, ischemia-reperfusion injury, cardioprotection, calcium channels, mitochondria, myocardial metabolism
Бібліографічний опис
Beschasnyi S. Small doses of carbon monoxide from the CORM-2 donor drug reduce ischemia-reperfusion damage to the heart / Beschasnyi S., Hasiuk O. //