Наукові праці дослідників університету
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монографії, наукові статті, тези, доповіді
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Item type:Item, Цитокіндетерміновані механізми патоморфологічної реалізації гастроезофагеальної рефлюксної хвороби на тлі автоімунного тиреоїдиту в осіб молодого віку(2024) Железнякова, Н.М.; Бочарова, Т.В.; Пасієшвілі, Л.М.; Пасієшвілі, Т.М.Item type:Item, Peculiarities of the clinical picture and diagnosis of dirofilariasis in the maxillofacial area: a series of cases from practice(2024) Buniatian, Khristina; Khotimska, Yulia; Kovach, Ilona; Yaroslavska, Yulia; Bondarenko, Olena; Nazaryan, RosanaDirofilariasis is a helminthiasis that occurs in carnivorous animals (dogs, cats, foxes, wolves, etc.) and less often in humans, although according to some authors it is believed that the number of infected animals approximately corresponds to the number of infected people. Dirofilariasis of the maxillofacial area is not a widespread condition, its cases are described in short series, therefore, the aim of this work is to share our own experience of managing patients with this rare condition.The work presents our own experience in the management of 14 dirofilariasis patients with lesions of the maxillofacial area, of them there are 3 men and 11 women aged 29 to 54. Most patients sought help in the late autumn, winter and spring periods and only 2 people in the summer period. All patients were examined by a dentist, and an ultrasound examination of the area with a formation was performed. According to the clinical manifestations, the disease began acutely in nine patients and had a picture of inflamed atheroma (2 – in the zygomatic area, 1 – in the parotid, 2 – in the infraorbital area, 2 – in the temporal area, and 2 – in the area of the nasal bridge). All patients were operated on and tumor-like formations in dense membranes were removed, inside which one live nematode 11-18 cm long was found. In 3 observations, fragments of dead, partially lysed nematodes were removed from the oral cavity, the capsules of which imitated a migrating granuloma. According to the location – 5 capsules with dirofilaria were located in the subcutaneous fatty tissue, 3 – in the submucosal layer of the gums fused to the periosteum of the upper jaw, 1 – in the submucous layer of the lower jaw, 2 – in the fibers of the temporalis muscle and 1 – in the fibers of the buccal muscle. In each case, the localization of the nematode was close to the places of accumulation of adipose tissue or large blood vessels. In the postoperative period complex therapy was prescribed, including symptomatic anti-inflammatory and desensitizing agents, and consultation with infectionist was recommended. Thus, according to our observations, dirofilariasis most often affects areas of the face in which there are large vessels and accumulation of fatty tissue. In connection with the prevalence of dirofilariosis in humans and the predominant localization of parasitic infection in the face area, dentists, ophthalmologists and otolaryngologists need to be familiar with this pathology and show definite vigilance. Treatment dirofilariosis patients should be carried out comprehensively, together with parasitologists, with surgical excision of the lesion and appropriate drug therapy.Item type:Item, Anatomical features of the ostiomeatal complex and their impact on complications in dental implantation(2025) Nazaryan, R.; Sosonna, L.; Iskorostenska, O.; Storozheva, M.; Fomenko, Yu.; Heranin, S.; Ohurtsov, O.; Nikonov, A.; Alekseeva, V.The anatomical structure of the ostiomeatal complex (OMC) plays a crucial role in the success of dental implantation procedures, particularly in the maxillary region. This study examines the anatomical variations of the OMC and their impact on postoperative complications in dental implantation. A total of 400 spiral computed tomography (CT) scans of patients aged 18 to 95 years were analyzed to assess key anatomical structures, including the maxillary sinus, concha bullosa, uncinate processes, and sinus ostium dimensions. Findings revealed significant anatomical variability, with concha bullosa observed in 33.2% of cases, uncinate process variations in 31.6%, and a narrowed maxillary sinus ostium in 6.25% of cases. These structural differences were found to influence sinus ventilation and drainage, thereby increasing the risk of postoperative complications such as sinusitis and impaired osseointegration. Statistical analysis highlighted strong correlations between sinus volume, bone thickness, and OMC components, reinforcing the need for thorough preoperative assessment. The study underscores the importance of personalized surgical planning and advanced imaging techniques in mitigating complications and optimizing dental implantation outcomesItem type:Item, Morphometric thresholds of the ostiomeatal complex and their psychological correlates in sinus ventilation impairment(2025) Yurevych, N.; Kysylenko, K.; Sukhina, I.; Falova, O.; Khartsiy, O.; Rozhkova, O.; Lupyr, M.; Alekseeva, V.The ostiomeatal complex (OMC) is a critical anatomical region ensuring ventilation and drainage of the anterior paranasal sinuses. Variability in its morphology can lead to functional impairment and predispose individuals to chronic rhinosinusitis. Objective: To determine quantitative morphometric thresholds associated with inadequate sinus ventilation based on OMC structure and semilunar hiatus dimensions using CT data and computational modeling. Methods: Morphometric analysis was performed on 400 spiral CT scans. OMC parameters were measured manually and automatically, and 3D models were constructed. Pressure and flow simulations were conducted using the IMED system. Subjects were divided into three groups based on the width of the semilunar hiatus: narrow, moderate, and wide. Parameters such as sinus wall thickness, OMC component density, and estimated ventilation pressure were analyzed. Results: Both excessively narrow (<1.8 mm) and overly wide (>3.5 mm) semilunar hiatuses were associated with impaired ventilation. Optimal airflow occurred in the intermediate range (2.1–3.2 mm). A pressure gradient of <2.5 Pa between the maxillary sinus and nasal cavity was associated with stasis in 73% of cases. Strong correlations were observed between sinus ventilation efficiency and the thickness of the uncinate process (r = –0.75, p < 0.01), as well as medial maxillary sinus wall thickness (r = –0.72, p < 0.05). Conclusion: Functional ventilation of the maxillary sinus requires a semilunar hiatus width between 2.1 and 3.2 mm and a pressure differential above 2.5 Pa. Both morphological extremes are associated with physiological dysfunction, highlighting the importance of patient-specific anatomical assessment in surgical planningItem type:Item, Anatomy of the maxillary sinus: implications for odontogenic sinusitis development(2024) Gorbik, E.; Ohurtsov, O.; Heranin, S.; Kolba, O.; Breslavets, N.; Sazonova, O.; Kysylenko, K.; Alekseeva, V.This study investigates the anatomical prerequisites that could contribute to the development of this condition. Material and methods: Using multi-slice computed tomography (MSCT), the study examined the structure and relationships of key anatomical features, including the alveolar process, sinus wall thickness, and the position of the teeth in relation to the maxillary sinus. The results revealed that the lower wall of the maxillary sinus is predominantly formed by the alveolar process, with significant variability in wall thickness, especially between the central and lateral regions. In 95% of cases, this wall was closely associated with the roots of the upper teeth, particularly the premolars. A strong negative correlation was observed between the thickness of the alveolar process and the volume of the maxillary sinus, suggesting that larger sinuses tend to have thinner alveolar processes. Additionally, a significant correlation was found between the position of the sinus and the degree of pneumatization, with a more medially positioned orbit in cases of reduced pneumatization.Conclusion: Structural features of the maxillary sinus, such as its proximity to the teeth and its relationship to sinus pneumatization, are critical factors in the development of odontogenic rhinosinusitis. A comprehensive, collaborative approach is necessary for effective management and prevention, with careful consideration of these anatomical aspects during dental and maxillofacial interventionsItem type:Item, CT-based study of anatomical variations in chronic rhinosinusitis patients(2025) Yurevych, N.; Varzhapetian, S.; Buniatian, Kh.; Khotimska, Yu.; Sukhina, I.; Kuzmenko, N.; Trach, O.; Alekseeva, V.Introduction: Chronic rhinosinusitis (CRS) is frequently associated with anatomical variations that may predispose individuals to impaired sinus drainage and mucosal inflammation. Computed tomography (CT) of the paranasal sinuses provides an essential diagnostic tool for evaluating these variations. Objective: To assess the prevalence and types of anatomical variations in patients with CRS using CT Data. Material and Methods: A retrospective cross-sectional study was conducted on 75 patients diagnosed with CRS. CT scans were evaluated for anatomical variations including concha bullosa, deviated nasal septum, agger nasi cells, Haller cells, Onodi cells, uncinate process variations, and paradoxical middle turbinate. Results: The most frequent variation observed was concha bullosa (64%), followed by deviated nasal septum (61.3%), agger nasi cells (49.3%), and Haller cells (32%). Onodi cells were observed in 21.3% of patients, uncinate process variations in 17.3%, and paradoxical middle turbinate in 12%. Conclusion: Anatomical variations are common in CRS patients and can play a critical role in the pathophysiology of the disease. CT imaging is vital in identifying these variations, which can guide appropriate surgical planning.Item type:Item, Морфометричні особливості взаємозв’язку коренів зубів із верхньощелепною пазухою(2025) Калашник-Вакуленко, Юлія Михайлівна; Kalashnyk-Vakulenko, Yu.; Побережник, Галина Анатоліївна; Poberezhnyk, Galyna; Сухіна, Ірина Сергіївна; Sukhina, Iryna; Котелевець, Я.; Kotelevets, Ya.; Алєксєєва, В.В.; Alieksieieva, V.Актуальність. Анатомічний зв’язок між задніми верхньощелепними зубами та верхньощелепною пазухою має велике клінічне значення у стоматології, отоларингології та щелепно-лицевій хірургії. Мета роботи – дослідити анатомічні взаємовідношення між коренями зубів і верхньощелепною пазухою за допомогою комп’ютерної томографії та оцінити їхнє клінічне значення. Матеріали та методи. Проведено ретроспективний аналіз 120 спіральних сканів комп’ютерної томографії дорослих пацієнтів віком 20–75 років. Вимірювали відстань від верхівок коренів до дна пазухи, товщину кісткової пластинки, ступінь виступання коренів у порожнину та морфометричні параметри пазухи. Результати. Найтісніший зв’язок із дном пазухи виявлено у перших і других молярів, особливо в мезіально-щічного кореня першого моляра. У 12% випадків відсутня суцільна кісткова пластинка між коренями та пазухою. Вікове збільшення пневматизації призводило до зменшення товщини кістки у ділянці дна пазухи, тоді як об’єм пазухи негативно корелював із її товщиною (r = –0,58, p < 0,001). Пряме виступання коренів у пазуху асоціювалося з підвищеним ризиком одонтогенного гаймориту (p < 0,01). Висновки. Взаємозв’язок між коренями задніх зубів і верхньощелепною пазухою характеризується значною індивідуальною варіабельністю. Передопераційна оцінка комп’ютерних томограм є обов’язковою для планування лікування в ендодонтії, імплантології та хірургії пазух з метою зниження ризику ускладнень.Item type:Item, Аnatomical variability of the ethmoid and sphenoid sinuses(2025) Yurevych, N.; Pokotylo, Р.; Podoliuk, M.; Seleznova, R.; Voinytska, O.; Vdovichenko, V.; Sukhonosov, R.; Alekseeva, V.The ethmoid and sphenoid sinuses exhibit marked anatomical variability that can impact surgical approaches and predispose individuals to complications during sinus and skull base procedures. Objective: To characterize the morphometric patterns and anatomical variants of the ethmoid and sphenoid sinuses based on high-resolution CT data and to analyze their surgical and clinical significance. Methods: A total of 400 CT scans were analyzed. Sinuses were classified by pneumatization type, dimensions, and presence of anatomical variants. 3D reconstructions were performed to assess spatial orientation and proximity to neurovascular structures. Results: Ethmoid sinus complexity was classified into three distinct types, with higher complexity correlating with narrower surgical corridors and increased risk of incomplete ethmoidectomy. Sphenoid pneumatization showed significant variability, including presellar, sellar, and postsellar types. Onodi cells were identified in 13% of cases, closely related to the optic canal. Septated sphenoids were present in 21%, often traversing the internal carotid artery canal. Conclusion: Detailed anatomical understanding of posterior sinus morphology and variation is essential for safe and effective sinus and skull base surgery. This study provides a morphometric atlas to support individualized surgical planningItem type:Item, Variant anatomy of the maxillary sinus based on multispiral computed tomography data (msct)(2024) Sosonna, L.; Yurevych, N.; Lupyr, M.; Babiy, L.; Kysylenko, K.; Kachailo, I.; Narbutova, T.; Borisenko, Ye.; Baiazitov, D.; Alekseeva, VThe structural features of the paranasal sinuses play a key role in the development of pathological processes within them. The aim of our study was to examine the variations in the anatomical structure of the maxillary sinus based on MSCT data.Item type:Item, Anatomical variability of the alveolar process of the maxilla based on multislice computed tomography data(2024) Shiyan, D.; Kysylenko, K.; Trach, O.; Yurevych, N.; Lupyr, M.; Alekseeva, V.Modern research methods, widely implemented in routine medical practice, open new horizons for the study of anatomical structures. The maxilla is one of the regions of the human skull that shows significant variability with age and gender. This is due to the peculiarities of tooth eruption and age-related changes in the periodontium and adjacent structures, which undoubtedly affect the structure of the alveolar process, sometimes drastically altering it over time.