Conceptual and theoretical exploration of treatment of patients with onychomycosis

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dc.contributor.authorChekhovska, G.S.
dc.contributor.authorPustova, N.O,
dc.contributor.authorChaplyk-Chyzho, I.O,
dc.contributor.authorKachailo, I.A.
dc.contributor.authorSypalo, A.O,
dc.contributor.authorGradil, G.I.
dc.contributor.authorLytvynenko, M.V.
dc.contributor.authorLobashova, K.G.
dc.contributor.authorPiriatinska, N.E.
dc.contributor.authorKudriavtseva, T.O.
dc.contributor.authorGargin, V.V.
dc.date.accessioned2026-01-08T07:54:39Z
dc.date.available2026-01-08T07:54:39Z
dc.date.issued2025
dc.description.abstractObjective: To optimize medical care for patients with onychomycosis by adding agents that improve nail plate structure to systemic antifungal therapy. Materials and methods: The study included 147 patients aged 23–79 years with various forms of onychomycosis of hands and feet. Patients were randomized into a main group receiving a systemic antifungal drug plus a biotin-containing agent aimed at improving nail plate structure and regrowth, and a control group receiving systemic antifungal therapy only. Diagnostic assessment included microscopy of nail fragments, culture, PCR, epiluminescence surface microscopy, dermatoscopy, and calculation of a nail plate damage index. Results: Combined therapy increased nail plate growth rate 1.4-fold compared with control (0.77±0.02 cm vs 0.53±0.03 cm). Conclusions: A comprehensive approach combining antifungal treatment with nail-structure–supporting agents provides mycological elimination and better clinical outcomes, achieving mycological remission at 10–12 weeks in 89.1% of patients, which is 19.5% higher than with traditional treatment. Restoration of normal nail plate structure was achieved in 96.8% of patients (vs 81.5% in controls).
dc.identifier.citationConceptual and theoretical exploration of treatment of patients with onychomycosis / G.S, Chekhovska [at al] // Georgian Medical News. - 2025. - Vol. 6(363). - P. 158–166. - ISSN 1512-0112.
dc.identifier.issn1512-0112
dc.identifier.urihttps://dspace.khimu-library.com.ua/handle/123456789/510
dc.language.isoen
dc.subjectOnychomycosis
dc.subjecttreatment
dc.subjectmorphology
dc.subjectnail plate
dc.subjectantimycotics
dc.titleConceptual and theoretical exploration of treatment of patients with onychomycosis
dc.typeArticle
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