Перегляд за Автор "Vekilov, V.N."

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    Molecular and clinical significance of ROS1 gene alterations in lung cancer patients: a retrospective analysis from Azerbaijan (2019–2023)
    (2025) Mehdizadeh, S.G.; Vekilov, V.N.
    This first study on ROS1 gene alterations in Azerbaijani non-small cell lung cancer (NSCLC) patients retrospectively analyzed 110 cases diagnosed between 2019 and 2023. ROS1 rearrangements were identified in 12 patients (10.9%) using RT-PCR, a rate higher than the global 1–2%, likely due to selection bias. ROS1-positive patients were predominantly female (58.3%) and non-smokers (75%), aligning with international data. The majority were diagnosed at advanced stages (66.7%). The median overall survival was short (8.13 months), attributed to limited access to ROS1-targeted tyrosine kinase inhibitors. The study highlights the urgent need for routine molecular screening and improved access to targeted therapy to enhance diagnostic precision and clinical outcomes in Azerbaijan.