Перегляд за Автор "Nikolchenko, A.Yu."

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  • Ескіз
    Документ
    Aspects of the induced stem cells therapeutic use
    (СГ НТМ «Новий курс», 2023) Nikolchenko, A.Yu.; Tynynyka, L.N.
  • Ескіз
    Документ
    Biological Aspects of Actovegin’s Action
    (2025) Nikolchenko, A.Yu.; Tynynyka, L.M.; Kudryavtseva, T.O.
    Actovegin is a protein-free hemodialysate derived from calf blood, containing low-molecular-weight peptides, nucleotides, oligosaccharides, and metabolic intermediates with molecular weights below 5 kDa. The present article analyzes the biological mechanisms underlying Actovegin’s pharmacological action, with a focus on its insulin-like effects and metabolic activity. Experimental studies demonstrate that Actovegin enhances cellular uptake and utilization of glucose and oxygen, stimulates pyruvate dehydrogenase activity, and improves aerobic energy metabolism without interacting with insulin receptors. Its action occurs at the post-receptor level, making it effective even under conditions of insulin resistance. Particular attention is paid to the role of oligosaccharides as secondary signaling molecules involved in lipogenesis and glucose transport modulation. Actovegin has been shown to improve cellular energy status during hypoxia and ischemia, enhance wound healing, and support tissue regeneration in peripheral arterial disease, diabetes-related complications, cerebral ischemia, and musculoskeletal injuries. In addition, angioprotective, cytoprotective, antioxidant, and anti-inflammatory properties contribute to its clinical efficacy. The reviewed data support the broad therapeutic potential of Actovegin in conditions associated with impaired metabolism, hypoxia, and microcirculatory disorders.
  • Ескіз
    Документ
    The role of outer membrane proteins in the structure of bacterial cell walls
    (ПВНЗ «Харківський міжнародний медичний університет», 2024) Tynynyka, L.N.; Nikolchenko, A.Yu.
    The article examines the role of outer membrane proteins in the structural organization of bacterial cell walls, with a particular focus on gram-negative bacteria. Special attention is given to the lipopolysaccharide outer membrane, which provides protection against host defense mechanisms, antibiotics, and environmental stress factors. The structural and functional features of porins as trimeric outer membrane proteins are highlighted, emphasizing their stability, resistance to denaturation, and dual role in both bacterial survival and host-pathogen interactions. Porins act as key effectors of pathogenesis, modulating immune responses and ensuring the persistence of bacteria within the host organism. At the same time, they serve as target molecules for the innate and adaptive immune system. The study also underlines the importance of developing research competence among medical students by integrating biochemical and microbiological investigations into the educational process. This approach contributes to a deeper understanding of antibiotic therapy and the treatment of infectious diseases caused by pathogenic microorganisms.