KHIMU Repository :: browse.title.page

Зараз показуємо 1 - 1 з 1

Clinical and biochemical significance of renal biomarkers in patients with chronic kidney disease depending on the presence of diabetes mellitus
(2025) Almammadov, F.Ch.
The study assessed changes in clinical indicators and renal injury biomarkers (cystatin C, NGAL, KIM-1, L-FABP, FGF-23, endothelin-1, and vitamin D) in 147 patients with various stages of chronic kidney disease (CKD), stratified by the presence of type 2 diabetes mellitus (DM2). The presence of DM2 significantly accelerated CKD progression, evidenced by a sharper decline in GFR (by 45% in diabetics vs 39% in non-diabetics) and more pronounced decreases in vitamin D levels. Diabetic patients showed higher levels of key biomarkers: NGAL, KIM-1, L-FABP, FGF-23, and endothelin-1, peaking at the terminal stage and confirming enhanced metabolic and inflammatory disturbances, and structural nephron damage. Cystatin C, KIM-1, and FGF-23 were identified as the most sensitive indicators for early diagnosis and prognosis of renal function decline.